David Glidden associated with the University of California, San Francisco, introduced split studies associated with the pharmacodynamics of tenofovir and emtricitabine as measured in 19 HIV negative volunteers.
He discovered that tenofovir only ever reached one tenth the amount in cervical muscle cells since it did in rectal muscle cells and that, moreover, it took longer to approach such maximum amounts about five times into the anus versus 10 12 times into the cervix.
When it comes to defense against transmission via rectal intercourse, Glidden calculated that 77% security against HIV ended up being reached after one dose of tenofovir. This might be more than the 38% recommended by way of a rectal explant research, even though the reduced bound associated with the self- self- confidence period in this research is 40%. Estimated protection is 89% after two doses, and 98% after three: a past substudy regarding the iPrEx PrEP research determined that four doses per week could be sufficient to provide basically 100% defense against HIV. Continue reading In this context, it really is notable that the Ipergay regimen provides much greater timing flexibility